AI Article Synopsis
- The intestine maintains homeostasis through a balance of intestinal stem cells, regulated by Notch and insulin signaling pathways.
- The study finds that the microRNA miR-305 is crucial for gut homeostasis, as it regulates these pathways in stem cells.
- miR-305's expression is influenced by nutritional factors, linking nutritional status to the regulation of stem cell self-renewal and differentiation in the gut.
Article Abstract
Homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. The balance between stem cell self-renewal and differentiation is regulated by the Notch and insulin signaling pathways. Dependence on the insulin pathway places the stem cell pool under nutritional control, allowing gut homeostasis to adapt to environmental conditions. Here we present evidence that miR-305 is required for adaptive homeostasis of the gut. miR-305 regulates the Notch and insulin pathways in the intestinal stem cells. Notably, miR-305 expression in the stem cells is itself under nutritional control via the insulin pathway. This link places regulation of Notch pathway activity under nutritional control. These findings provide a mechanism through which the insulin pathway controls the balance between stem cell self-renewal and differentiation that is required for adaptive homeostasis in the gut in response to changing environmental conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215186 | PMC |
| http://dx.doi.org/10.1101/gad.241588.114 | DOI Listing |
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