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Conflict-affected regions face severe reproductive health challenges that disproportionately impact adolescent girls and young women (AGYW) and children, who are especially vulnerable due to the breakdown of healthcare systems and limited access to essential services. AGYW are at heightened risk due to restricted access to family planning, prenatal care, and emergency obstetric services, while children face malnutrition, disease outbreaks, and developmental delays. These challenges have profound long-term consequences for both their physical and psychological well-being.

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Background: Reportable sexually transmitted infections (STIs) have increased in California, with dramatic rises in prenatal and congenital syphilis. In response, in 2018 Planned Parenthood Northern California implemented 2 opt-out screening protocols: (1) HIV, chlamydia, gonorrhea, and syphilis co-screening for pregnant patients at pregnancy diagnosis and (2) linking HIV and syphilis screening for all patients.

Methods: Using qualitative analyses, we explored implementation barriers and facilitators that can be addressed by clinical leadership and staff to expand uptake of enhanced screening protocols.

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Article Synopsis
  • Total anomalous pulmonary venous return (TAPVR) can cause severe issues shortly after birth, making early detection crucial for better outcomes.
  • Despite being a serious congenital heart condition, TAPVR is often not diagnosed before birth, even though there are known ultrasound markers.
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PIK3CA-Related Overgrowth Spectrum: Exploring Brain Growth From Fetal to Infant.

Pediatr Neurol

November 2024

Department of Neonatology, Unidade Local de Saúde de Vila Nova de Gaia, Vila Nova de Gaia, Portugal.

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  • MCAP (Megalencephaly-capillary malformation-polymicrogyria syndrome) is a rare neurological disorder caused by mutations in the PIK3CA gene, leading to abnormal brain growth, vascular issues, and body overgrowth.
  • A clinical report details an infant diagnosed with MCAP, who showed signs of the disorder from prenatal imaging, which identified megalencephaly and a confirmed PIK3CA mutation postnatally, followed by early medical interventions.
  • Despite these interventions, the patient faced ongoing challenges such as macrocrania, hydrocephalus, and neurodevelopmental delays, highlighting the importance of multidisciplinary care and monitoring to manage the complexities of the disorder and emphasizing potential future therapies for better outcomes.
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