AI Article Synopsis
- The study explores prospective memory in first-degree relatives of schizophrenia patients, first episode schizophrenia patients, and healthy controls.
- The research involved 47 FES patients, 50 non-psychotic FDRs, and 51 HCs using a specific memory test to evaluate performance.
- Results showed that FDRs had significant prospective memory impairments compared to the other groups, indicating these deficits may be a characteristic feature associated with schizophrenia.
Article Abstract
Objective: We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).
Methods: Forty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.
Results: After controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.
Conclusions: FDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218767 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111562 | PLOS |
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