Isoproterenol (ISO), at concentrations of up to 10(-5) mol/L, caused a dose-dependent stimulation of cyclic AMP (cAMP) production in rat cardiomyocytes. At higher ISO concentrations, relative inhibition was seen. Insulin augmented ISO-stimulated cAMP production and appeared to mitigate the toxic effects of high ISO concentrations. This synergy between insulin and ISO observed in cardiomyocytes was not observed in adipocytes. Streptozotocin (STZ)-diabetes abolished the stimulatory effects of insulin on ISO-induced cAMP production in cardiomyocytes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0026-0495(89)90246-1DOI Listing

Publication Analysis

Top Keywords

iso concentrations
12
camp production
12
effects insulin
8
cyclic amp
8
insulin streptozotocin-diabetes
4
streptozotocin-diabetes isoproterenol-stimulated
4
isoproterenol-stimulated cyclic
4
production
4
amp production
4
production myocytes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!