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Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth.
JAMA
January 2025
Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: T helper 2 (T2) cells and T helper 17 (T17) cells are CD4+ T cell subtypes involved in asthma. Characterizing asthma endotypes based on these cell types in diverse groups is important for developing effective therapies for youths with asthma.
Objective: To identify asthma endotypes in school-aged youths aged 6 to 20 years by examining the distribution and characteristics of transcriptomic profiles in nasal epithelium.
[Analysis of the sensitization characteristics and changes trend of common allergens in a hospital of pediatric in Beijing City from 2019 to 2023].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Allergy, National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing100045, China.
Article Synopsis
- The study examined changes in specific IgE (sIgE) test results for common allergens in children hospitalized from 2019 to 2023 to assist in diagnosing allergic diseases.
- A total of 44,633 test results were analyzed, split between food and inhaled allergens, revealing significant yearly increases in positive rates for both categories.
- Age-related differences in sensitization patterns were observed, with egg white being the most common food allergen in infants, and peanut allergies becoming prevalent in older children and adolescents.
Chlorinated paraffins in particulate matter associated with asthma and its relative symptoms in school-aged children and adolescents: A cross-sectional survey in South China.
Sci Total Environ
December 2024
Inhalation toxicology laboratory, Department of Environmental and Biological Science, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland.
Particulate matter (PM) and contaminants attached to PM can increase the risk of respiratory diseases. However, the health risk assessment of chlorinated paraffins (CPs), an emerging pollutant occupying a high proportion of persistent organic pollutants (POPs) in PM, remains scarce. This study aimed to evaluate the association between PM-bound CPs and asthma, along with relative symptoms, in school-aged children and adolescents.
View Article and Find Full Text PDFDouble-Blind, Placebo-Controlled Trial of the Efficacy and Safety of Azelastine Hydrochloride in Children with Perennial Allergic Rhinitis.
Int Arch Allergy Immunol
December 2024
Allergy & Asthma Solutions, Coto de Caza, California, USA.
Introduction: Allergic rhinitis (AR) affects up to 40% of the pediatric population. The US practice parameter recommends the use of intranasal antihistamines (INAH) or INCS as first-line therapy for the treatment of AR. Although not directly targeted to children, the recent US practice parameters proposed INAH as first-line therapy whereas the ARIA guidelines did not.
View Article and Find Full Text PDFVentilation in school and students' health after outbreak of COVID-19: A systematic literature review.
Afr J Reprod Health
October 2024
Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
Ventilation is one of the factors that support the health of students needed to support the goals of education. The objective of this study is to analyze how ventilation at school impacts the health of students. Scopus and Web of Science were used to retrieve published articles on ventilation at school and students' health.
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