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As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.
View Article and Find Full Text PDFNebulised high-dose corticosteroids as add-on therapy for adults with asthma exacerbation: a randomised controlled trial.
Emerg Med J
December 2024
Emergency Department, Vajira Hospital, Navamindhathiraj University, Dusit, Bangkok, Thailand.
Background: Evidence regarding high-dose inhaled corticosteroids (HDICS) in asthma exacerbations in adults is insufficient. This study compares the treatment outcomes of HDICS as add-on therapy to the outcomes of standard treatment in adult patients with acute asthma exacerbation in the ED.
Methods: This was a single-centre, triple-blind, randomised controlled trial conducted in the ED in Thailand between March 2022 and April 2023.
Severe pneumonia caused by combined with infection: a case report.
Am J Transl Res
November 2024
Department of Emergency, Changhai Hospital Affiliated to Naval Medical University Shanghai 200433, The People's Republic of China.
is an obligate aerobic, Gram-negative bacillus belonging to the family of Weeksellacease. In recent years, there has been a gradual increase in related infections, especially in chronically hospitalized, immunocompromised populations that often develop severe pneumonia. Severe pneumonia is one of the common critical illnesses.
View Article and Find Full Text PDFComparative adherence and persistence of single-inhaler and multiple-inhaler triple therapies among patients with chronic obstructive pulmonary disease in Japan: a retrospective cohort study.
BMJ Open
December 2024
Value Evidence and Outcomes, R&D Global Medical, GlaxoSmithKline, London, UK
Objectives: To evaluate and compare medication adherence and persistence for patients newly initiating single-inhaler triple therapy (SITT) and multiple-inhaler triple therapy (MITT) for chronic obstructive pulmonary disease (COPD) in Japan.
Design: Retrospective, new-user, active comparator, observational cohort study using inverse probability of treatment weighting.
Setting: Health insurance claims data from the Medical Data Vision Co.
[Efficacy and safety assessment of transnasal nebulisation of budesonide in children with adenoid hypertrophy].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2024
To investigate the efficacy and assess the safety of transnasal nebulisation of budesonide in children with adenoid hypertrophy. Children with adenoid hypertrophy who attended the Children's Hospital of Zhejiang University School of Medicine between December 2021 and December 2022 were randomly assigned to budesonide high-dose group（Group A: budesonide 1 mg/dose + saline nasal rinse）, budesonide low-dose group（Group B: budesonide 0.5 mg/dose + saline nasal rinse）, and control group（Group C: saline nasal rinse）, and each group 20 children were collected separately, The efficacy and safety of transnasal nebulisation of budesonide in children with adenoid hypertrophy were assessed by comparing the symptomatic VAS scores, adenoidal nasopharyngeal lateral radiographs A/N values, nocturnal sleep oximetry（SaO2）, and the incidence of adverse events during the treatment period of 8-week in the three groups.
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