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Major role of dolutegravir in the emergence of the S147G integrase resistance mutation.
J Antimicrob Chemother
December 2024
Department of Virology, Sorbonne Université, INSERM, UMR-S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, 83 Boulevard de l'Hôpital 39, F-75013 Paris, France.
Background: The S147G mutation is associated with high-level resistance to the integrase strand transfer inhibitor (INSTI) elvitegravir. In several poorly documented cases, it was also selected in patients on dolutegravir. Given the widespread use of dolutegravir, further studies of S147G are required.
View Article and Find Full Text PDFBackground: Understanding the genetic etiology of Alzheimer's disease (AD) has been a major focus of research in neurodegenerative diseases. Amid the three common allelic variants of the apolipoprotein E (APOE) gene in humans, called APOE ε2, ε3 and ε4, the ε4 allele is the most common genetic risk factor for late-onset AD, being found in 20% of the world population.
Method: We used Event-Related Potentials (ERP) and Event-Related Spectral Perturbation (ERSP) as features for classification of apolipoprotein E ϵ4 (APOE ε4) allele carriers in AD patients and healthy controls.
Background: Sleep deficiency is associated with an increased risk of Alzheimer's disease (AD), warranting research on underlying mechanisms. This study examined the association of sleep architecture with anatomical features frequently observed in AD: (1) atrophy of cuneus, hippocampus, entorhinal, inferior parietal, parahippocampal, and precuneus regions (henceforth referred to as "AD-vulnerable regions") and (2) the presence of cerebral microbleeds.
Method: In 271 participants of the Atherosclerosis Risk in the Communities Study, we examined the prospective association of baseline sleep architecture with anatomical features of the brain identified on MRI conducted ∼17 years later.
Biomarkers.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: TDP-43 (TAR DNA-binding protein 43) is one of the most frequently observed co-pathologies in Alzheimer's disease (AD). Recognizing the diversity of pathological features in individuals with AD, including the presence of TDP-43, may lead to more personalized and effective treatment approaches. We investigate ante-mortem cortical microstructural changes in MRI with subsequent autopsy confirmation of Alzheimer's disease neuropathological changes (ADNC) with and without TDP-43 comorbidity.
View Article and Find Full Text PDFBackground: Alzheimer's Disease (AD) and traumatic brain injuries (TBI) are frequently associated in medical literature, with a significant prevalence of TBI history observed among individuals diagnosed with AD. Our investigation focuses on this intersection, explicitly examining the risk of AD in individuals with a history of TBI. While current targets in cerebrospinal fluid and plasma can effectively detect acute TBI, the challenge lies in identifying biosignatures associated with TBI long after injury.
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