Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.

Kang-Hsi Wu Tefu Weng Han-Ping Wu Ching-Tien Peng Ji-Nan Sheu Yu-Hua Chao

Pediatr Infect Dis J

From the *School of Chinese Medicine, China Medical University; †Department of Pediatrics, China Medical University Hospital; ‡Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Taichung Branch; §Department of Biotechnology and Bioinformatics, Asia University; ¶Department of Pediatrics; and ‖School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Published: November 2014

Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).

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http://dx.doi.org/10.1097/INF.0000000000000407	DOI Listing

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