Objective: Patients with Parkinson's disease (PD) often have deficits with mental rotation (MR). The neuropathological factors underlying these deficits, however, remain to be elucidated. One hypothesis suggests that dopamine depletion in nigro-striatal systems adversely influences MR. Another hypothesis suggests that deterioration of cortical (fronto-temporo-parietal basal ganglia) networks that mediate this function are responsible for this deficit. The goal of this study was to test the dopamine hypothesis by determining if dopamine abstinence negatively influences MR performance.
Methods: Thirty three non-demented right-handed individuals with PD were assess for their ability to perform a pencil and paper MR test while "on" and "off" dopaminergic medications. Dopamine abstinence followed the typical overnight withdrawal procedures.
Results: No differences in mental rotation abilities were found between "on" and "off" dopaminergic medications.
Conclusions: These results suggest that other neuropathological factors, such as cortical-basal ganglia neurodegeneration, or dysfunction of other neurotransmitters systems, might account for these cognitive deficits and future research will have to test these alternative hypotheses.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213535 | PMC |
| http://dx.doi.org/10.14802/jmd.14011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improved patient reported outcomes with knotless double-row rotator cuff repair with and without lateral row biceps tenodesis at 2- and 5-years.
JSES Int
November 2024
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: The purpose of this study is to report outcomes of an arthroscopic knotless double-row (DR) rotator cuff repair (RCR) technique at 2- and 5- years postoperatively, and to compare clinical outcomes in patients undergoing knotless DR RCR with incorporated lateral row biceps tenodesis (LRT) vs. those without LRT.
Methods: All primary RCR surgeries were performed by a single surgeon at a single institution using a knotless transosseous equivalent (TOE) technique.
Association of self-monitoring performance of cognitive performance with personal diurnal preference when sleep-deprived.
Chronobiol Int
January 2025
Research Center for Overwork-Related Disorders, National Institute of Occupational Safety and Health, Kawasaki, Japan.
In modern society, many workers struggle with sleep deprivation due to their work schedules and excessive workloads. Accurate self-awareness and self-monitoring abilities are crucial for workers to adopt risk-coping strategies and protective behaviors when fatigued. The current study examined the relationship between chronotypes and self-monitoring performance during 24 h of sleep deprivation.
View Article and Find Full Text PDFThe cost of perspective switching: Constraints on simultaneous activation.
Psychon Bull Rev
January 2025
Department of Education and Psychology, The Open University, 1 University Road, P.O. Box 808, 4353701, Ra'anana, Israel.
Visual perspective taking often involves transitioning between perspectives, yet the cognitive mechanisms underlying this process remain unclear. The current study draws on insights from task- and language-switching research to address this gap. In Experiment 1, 79 participants judged the perspective of an avatar positioned in various locations, observing either the rectangular or the square side of a rectangular cube hanging from the ceiling.
View Article and Find Full Text PDFHow Do Psychiatry Residents View Their Training in Spain? A Mixed-Method Survey.
Actas Esp Psiquiatr
January 2025
Psychiatry Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain; Research Group on Psychiatry and Neurodegenerative Diseases, INCLIVA-Instituto de Investigación Sanitaria, 28009 Valencia, Spain; CIBERSAM-Centro de Investigación Biomédica en Red de Salud Mental, 28029 Madrid, Spain; Medicine Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Background: Efforts to improve psychiatry training must incorporate residents' assessment of their training. This study sought to collect the opinion of residents about the program that has been in force in Spain since 2008, until the current transition to a new plan.
Methods: The authors conducted an online survey of psychiatry residents in Spain, asking about their formative and working conditions.
Cervical Defect Reconstruction Using Preexpanded Neck Flaps Transferred in a Scarf-wrapping Manner.
J Craniofac Surg
January 2025
Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan, Beijing, P.R. China.
Objective: Cervical burn scar contractures can be repaired using many modalities, including skin grafts, pedicled and free flaps. Although preexpanded cervical flaps can provide a like-with-like reconstruction, a simple advancement transfer of the flaps often fails to achieve ideal outcomes. The authors aimed to introduce a method using the preexpanded cervical flaps transferred in a scarf-wrapping manner to repair neck defects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!