AI Article Synopsis
- Polycystic ovary syndrome (PCOS) is linked to cardiovascular risks and recent studies have shown a connection between increased prolactin (PRL) levels and platelet activation, specifically the mean platelet volume (MPV) in women with PCOS.
- A cross-sectional study analyzed three groups: women with PCOS and mildly elevated PRL levels, women with normal PRL levels, and healthy controls, measuring various health indicators like blood counts and glucose levels.
- Findings revealed that women with PCOS and elevated PRL had significantly higher MPV levels, indicating a possible increased risk of cardiovascular issues due to platelet activation associated with prolactin.
Article Abstract
Objective: Polycystic ovary syndrome (PCOS) is associated with cardiovascular risk factors including hypertension, obesity, hyperlipidaemia and glucose intolerance. Several studies demonstrated the link between PCOS and an increased risk of cardiovascular disease. Platelets play a crucial role in the development of atherothrombotic disease. Mean platelet volume (MPV) is a marker of platelet size that reflects its activity. Research points to a link between prolactin (PRL) and platelet activation. The purpose of this study was to investigate whether prolactin levels are associated with MPV in women with PCOS.
Design: The research was designed as a cross-sectional study.
Patients: Participants were divided into three groups-PCOS patients with mildly elevated PRL levels (n = 72), patients with PCOS with normal PRL levels (n = 207) and healthy controls (n = 90). They were body mass index and age-matched and consecutively recruited.
Measurements: Complete blood counts, serum glucose, prolactin, insulin, lipids, high-sensitivity C-reactive protein and free-testosterone levels were measured.
Results: Among the three groups, MPV levels were higher in women with PCOS having mildly elevated PRL levels (P < 0·001) and MPV was found to be correlated with PRL levels (r = 0·387, P < 0·001). Multiple regression analysis showed that PRL levels were associated with MPV levels (R(2) = 0·239, β = 0·354, P < 0·001).
Conclusion: Mean platelet volume levels are significantly increased in women with PCOS having mildly elevated PRL. Our results suggest that there is a link between prolactin and MPV levels. In women with PCOS, elevated PRL levels may increase the risk of developing atherothrombotic events via the activation of platelets.
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| http://dx.doi.org/10.1111/cen.12647 | DOI Listing |
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