AI Article Synopsis
- The self-assembly of virus-like particles can create materials that merge virus-like features, such as size control and environmental responsiveness, with non-living materials.
- Various viruses allow their shell proteins to encapsulate non-genomic materials effectively in a protein structure.
- The chapter presents efficient protocols for assembling these viral protein cages around functionalized gold nanoparticles, applicable to several virus types, with the potential for easy adaptation to a range of different nanoparticles.
Article Abstract
The self-assembly of virus-like particles may lead to materials which combine the unique characteristics of viruses, such as precise size control and responsivity to environmental cues, with the properties of abiotic cargo. For a few different viruses, shell proteins are amenable to the in vitro encapsulation of non-genomic cargo in a regular protein cage. In this chapter we describe protocols of high-efficiency in vitro self-assembly around functionalized gold nanoparticles for three examples of icosahedral and non-icosahedral viral protein cages derived from a plant virus, an animal virus, and a human retrovirus. These protocols can be readily adapted with small modifications to work for a broad variety of inorganic and organic nanoparticles.
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| http://dx.doi.org/10.1007/978-1-4939-2131-7_1 | DOI Listing |
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