Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium.

Org Biomol Chem

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada.

Published: December 2014

Regioselective S-acylation of coenzyme A (CoA) is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters. Unlike many hydrophobic activating groups, the anionic methyl acyl phosphate mixed anhydride is more compatible with aqueous solvents, making it useful for conducting acylation reactions in an aqueous medium.

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Source
http://dx.doi.org/10.1039/c4ob02079kDOI Listing

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