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Exploring clinical chemistry markers in amyotrophic lateral sclerosis: insights into survival and disease trajectories.
J Neurol
December 2024
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Objective: Commonly measured clinical chemistry markers might be indicative of survival and disease progression in amyotrophic lateral sclerosis (ALS).
Methods: In a cohort study of 270 ALS patients diagnosed from April 2014 to May 2021 in Stockholm, Sweden, we examined the link between 29 clinical chemistry markers at diagnosis and mortality risk at 6 months, 1 year, and 3 years after diagnosis. Summary variables from exploratory factor analysis (EFA) assessed the markers' collective impact on survival.
Article Synopsis
- Background: The study focused on the effectiveness of tranexamic acid in preventing bleeding and reducing the need for platelet transfusions in patients with blood cancers receiving intensive treatment.
- Methods: An international trial (TREATT) involved 616 adults under chemotherapy or stem-cell transplant, who were randomly assigned to receive either tranexamic acid or a placebo while monitored for bleeding and platelet recovery.
- Findings: Out of 1736 screened patients, 597 were included in the final analysis, revealing demographic details and outcomes related to bleeding events and mortality rates among the two groups.
Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data.
Nat Commun
September 2024
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- - Individuals with mental illness are at a higher risk for severe COVID-19 outcomes, but studies on their vaccination uptake have shown mixed results.
- - This research analyzed data from multiple cohort studies and Swedish registers to explore the relationship between mental illness and COVID-19 vaccination rates.
- - Findings revealed that while overall vaccine uptake was high in both groups, there was a slight decrease in vaccination rates among unmedicated individuals with mental illness, indicating a need for further investigation into this subgroup.
Trends in sex differences in neurodevelopmental outcomes among extremely preterm infants.
Arch Dis Child Fetal Neonatal Ed
September 2024
Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, California, USA.
Objective: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants.
Design: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females.
Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus.
Arthritis Res Ther
September 2024
New York University Grossman School of Medicine, New York, NY, USA.
Article Synopsis
- The Manhattan Lupus Surveillance Program (MLSP) investigated cardiovascular disease events in systemic lupus erythematosus (SLE) patients and compared their rates to population controls based on sex, age, and race/ethnicity.
- In a study of 1,285 SLE patients, 13.9% experienced cardiovascular events, with higher risks associated with being male and over the age of 60.
- The study found that Hispanic/Latino and non-Hispanic Black patients had significantly elevated risks for cardiovascular events compared to other racial groups, highlighting a higher overall prevalence of these events among SLE patients compared to the general population.
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