TargetCompare: A web interface to compare simultaneous miRNAs targets.

Bioinformation

Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil ; Nucleo de Pesquisa em Oncologia, Universidade Federal do Para, Belem, PA, Brasil.

Published: October 2014

Unlabelled: MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.

Availability: http://lghm.ufpa.br/targetcompare.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209372PMC
http://dx.doi.org/10.6026/97320630010602DOI Listing

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