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Probing the properties of PTEN specific botulinum toxin type E mutants.
J Neural Transm (Vienna)
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Institut für Zellbiochemie, OE 4310, Medizinische Hochschule Hannover, 30623, Hannover, Germany.
Botulinum neurotoxins (BoNT) are established biopharmaceuticals for neuromuscular and secretory conditions based on their ability to block neurotransmitter release from neurons by proteolyzing specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Recently, a mutant catalytic domain of serotype E (LC/E) exhibiting 16 mutations was reported to cleave the phosphatase and tensin homolog (PTEN). This molecule represents an attractive new target in neurons as several reports support PTEN knockdown as a strategy to stimulate axonal regeneration after injury.
View Article and Find Full Text PDFA Markov decision optimization of medical service resources for two-class patient queues in emergency departments via particle swarm optimization algorithm.
Sci Rep
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Department of Anesthesiology, Changhua Christian Hospital, Changhua, 50050, Taiwan.
In the modern healthcare system, the rational allocation of emergency department (ED) resources is crucial for enhancing emergency response efficiency, ensuring patient safety, and improving the quality of medical services. This paper focuses on the issue of ED resource allocation and designs a priority sorting system for ED patients. The system classifies patients into two queues: urgent and routine.
View Article and Find Full Text PDFApplying implementation science frameworks to understand why fisherfolk continue or discontinue pre-exposure prophylaxis for HIV prevention in Uganda: a qualitative analysis.
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School of Public Health, Makerere University, Kampala, Uganda.
Introduction: In Uganda, fisherfolk have an HIV prevalence between 15% and 40%, significantly higher than the national average of 5.5%. Pre-exposure prophylaxis (PrEP) is effective in preventing HIV but faces challenges in uptake and continuation among fisherfolk.
View Article and Find Full Text PDFRice husk biowaste derived microcrystalline cellulose reinforced sustainable green composites: A comprehensive characterization for lightweight applications.
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Natural Composites Research Group Lab, Department of Mechanical and Process Engineering, The Sirindhorn International Thai-German Graduate School of Engineering (TGGS), King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok 10800, Thailand.
This study addresses the issue of waste generation within the food industry, focusing on the conversion of rice husk waste into value-added products. The investigation involves a comprehensive characterization of microcrystalline cellulose extracted from the rice husk and reinforcing them in bio-epoxy resin to determine its feasibility in producing ecofriendly products. The dried rice husk waste was made to undergo a series of treatments, including alkali, acid hydrolysis, and bleaching for extracting high purity microcrystalline cellulose.
View Article and Find Full Text PDFMicro-physiological system of human lung: The current status and application to drug discovery.
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Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. Electronic address:
Various attempts have been made to elucidate the mechanisms of human lung development, its physiological functions, and diseases, in the hope of new drug discovery. Recent technological advancements in experimental animals, cell culture, gene editing, and analytical methods have provided new insights and therapeutic strategies. However, the results obtained from animal experiments are often inconsistent with those obtained from human data because of reproducibility issues caused by structural and physiological differences between mice and humans.
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