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Switchable modes of azulene-based single molecule-electrode coupling controlled by interfacial charge distribution.
Chem Sci
December 2024
Center for Bioanalytical Chemistry, University of Science and Technology of China Hefei 230026 China
Molecule-electrode interactions are critical for determining transport mechanisms and device functionalities in both single-molecule electrochemistry and electronics. Crucial factors such as anchoring groups and local fields have been studied, but the role of electrolytes and interfacial charge distribution remains largely underexplored. The present research focuses on how the interfacial charge distribution in the electric double layer (EDL) controls single-molecule junctions anchored by azulene.
View Article and Find Full Text PDFSingle-Molecule Electrical Conductance in Z-form DNA:RNA.
Small
December 2024
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Nucleic acids have emerged as new materials with promising applications in nanotechnology, molecular electronics, and biosensing, but their electronic properties, especially at the single-molecule level, are largely underexplored. The Z-form is an exotic left-handed helical oligonucleotide conformation that may be involved in critical biological processes such as the regulation of gene expression and epigenetic processes. In this work, the electrical conductance of individual Guanine Cytosine (GC)-rich DNA:RNA molecules is measured in physiological buffer and 2,2,2-Trifluoroethanol (TFE) solvent, corresponding to the natural (right-handed helix) A-form typical in DNA:RNA hybrids and the (left-handed) Z-form conformations, respectively.
View Article and Find Full Text PDFModel supports asymmetric regulation across the intercellular junction for collective cell polarization.
PLoS Comput Biol
December 2024
Department of Mathematics, Northeastern University, Boston, Massachusetts, United States of America.
Symmetry breaking, which is ubiquitous in biological cells, functionally enables directed cell movement and organized embryogenesis. Prior to movement, cells break symmetry to form a well-defined cell front and rear in a process called polarization. In developing and regenerating tissues, collective cell movement requires the coordination of the polarity of the migration machineries of neighboring cells.
View Article and Find Full Text PDFDecoding the Nucleolar Role in Meiotic Recombination and Cell Cycle Control: Insights into Cdc14 Function.
Int J Mol Sci
November 2024
Instituto de Biología Funcional y Genómica, IBFG, CSIC-USAL, 37007 Salamanca, Spain.
The cell cycle, essential for growth, reproduction, and genetic stability, is regulated by a complex network of cyclins, Cyclin-Dependent Kinases (CDKs), phosphatases, and checkpoints that ensure accurate cell division. CDKs and phosphatases are crucial for controlling cell cycle progression, with CDKs promoting it and phosphatases counteracting their activity to maintain balance. The nucleolus, as a biomolecular condensate, plays a key regulatory role by serving as a hub for ribosome biogenesis and the sequestration and release of various cell cycle regulators.
View Article and Find Full Text PDFMapping the Extended Ground State Reactivity Landscape of a Photoswitchable Molecule at a Single Molecular Level.
J Am Chem Soc
December 2024
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Photoswitchable molecules with structural flexibility can exhibit a complex ground state potential energy landscape due to the accessibility of multiple metastable states at merely low energy barriers. However, conventional bulk analytical techniques are limited in their ability to probe these metastable ground states and their relative energies. This is partially due to the difficulty of inducing changes in small molecules in their ground state, as they do not respond to external stimuli, such as mechanical force, unless they are incorporated into larger polymer networks.
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