In the present work, we undertook the complete mitochondrial genome sequencing of an important liver cancer model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes and 1 non-coding control region (D-loop region). The mutation events were also reported.

Download full-text PDF

Source
http://dx.doi.org/10.3109/19401736.2014.974160DOI Listing

Publication Analysis

Top Keywords

complete mitochondrial
8
mitochondrial genome
8
liver cancer
8
cancer model
8
model inbred
8
rna genes
8
genome sequence
4
sequence mutations
4
mutations liver
4
inbred c57bl/6
4

Similar Publications

Comparative Analysis of Protist Communities in Oilsands Tailings Using Amplicon Sequencing and Metagenomics.

Environ Microbiol

January 2025

Division of Infectious Diseases, Department of Medicine, and Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

The Canadian province of Alberta contains substantial oilsands reservoirs, consisting of bitumen, clay and sand. Extracting oil involves separating bitumen from inorganic particles using hot water and chemical diluents, resulting in liquid tailings waste with ecotoxicologically significant compounds. Ongoing efforts aim to reclaim tailings-affected areas, with protist colonisation serving as one assessment method of reclamation progress.

View Article and Find Full Text PDF
Article Synopsis
  • Species in the Echeneidae family are known for their ability to attach to hosts using a sucking disc; this study analyzed the mitochondrial genomes of three such species.
  • The mitochondrial genomes varied slightly in length and contained essential genes for protein coding, rRNA, tRNA, and a D-loop region, with most genes demonstrating specific patterns in their codon usage and genetic structure.
  • Phylogenetic analysis revealed distinct relationships among the species, with one species forming its own group and the others being closely related, thus adding valuable data to the understanding of this fish family's classification.
View Article and Find Full Text PDF

ANAC044 orchestrates mitochondrial stress signaling to trigger iron-induced stem cell death in root meristems.

Proc Natl Acad Sci U S A

January 2025

Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

While iron (Fe) is essential for life and plays important roles for almost all growth related processes, it can trigger cell death in both animals and plants. However, the underlying mechanisms for Fe-induced cell death in plants remain largely unknown. S-nitrosoglutathione reductase (GSNOR) has previously been reported to regulate nitric oxide homeostasis to prevent Fe-induced cell death within root meristems.

View Article and Find Full Text PDF

The underlying mechanisms explaining the differential course of SARS-CoV-2 infection and the potential clinical consequences after COVID-19 resolution have not been fully elucidated. As a dysregulated mitochondrial activity could impair the immune response, we explored long-lasting changes in mitochondrial functionality, circulating cytokine levels, and metabolomic profiles of infected individuals after symptoms resolution, to evaluate whether a complete recovery could be achieved. Results of this pilot study evidenced that different parameters of aerobic respiration in lymphocytes of individuals recuperated from a severe course lagged behind those shown upon mild COVID-19 recovery, in basal conditions and after simulated reinfection, and they also showed altered glycolytic capacity.

View Article and Find Full Text PDF

We present the complete mitochondrial genome of from China. The mitogenome of is circular, AT-rich (75.3%), and 15,898 bp in length.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!