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Production of biologically active recombinant salmon calcitonin in Escherichia coli and fish cell line.
Arch Microbiol
January 2025
Aquatic Animal Health Laboratory, PG & Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Ranipet, Tamil Nadu, 632509, India.
Salmon calcitonin is a small peptide hormone synthesised and released by a specialised gland called ultimobranchial gland in fish. This hormone has been used to treat osteoporosis for over 50 years. The aim of this study was to compare the efficacy of five repeats of salmon calcitonin (5sCT) produced in two different hosts (bacteria and fish cell line).
View Article and Find Full Text PDFProphage-encoded chitinase gene supports growth of its bacterial host isolated from deep-sea sediments.
ISME J
January 2025
HADAL & Nordcee, Department of Biology, University of Southern Denmark, Odense, Denmark.
Auxiliary metabolic genes encoded by bacteriophages can influence host metabolic function during infection. In temperate phages, auxiliary metabolic genes may increase host fitness when integrated as prophages into the host genome. However, little is known about the contribution of prophage-encoded auxiliary metabolic genes to host metabolic properties.
View Article and Find Full Text PDFNucleic acid recognition during prokaryotic immunity.
Mol Cell
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Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address:
Parasitic elements often spread to hosts through the delivery of their nucleic acids to the recipient. This is particularly true for the primary parasites of bacteria, bacteriophages (phages) and plasmids. Although bacterial immune systems can sense a diverse set of infection signals, such as a protein unique to the invader or the disruption of natural host processes, phage and plasmid nucleic acids represent some of the most common molecules that are recognized as foreign to initiate defense.
View Article and Find Full Text PDFMolecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator.
Nucleic Acids Res
January 2025
Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, SAS Nagar, Mohali 140306, Punjab, India.
GntR/FadR family featuring an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal α-helical effector-binding and oligomerization domain constitutes one of the largest families of transcriptional regulators. Several GntR/FadR regulators govern the metabolism of sugar acids, carbon sources implicated in bacterial-host interactions. Although effectors are known for a few sugar acid regulators, the unavailability of relevant structures has left their allosteric mechanism unexplored.
View Article and Find Full Text PDFA plasmid-chromosome crosstalk in multidrug resistant enterobacteria.
Nat Commun
December 2024
Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Article Synopsis
- Conjugative plasmids like pOXA-48 contribute to the spread and evolution of antimicrobial resistance in bacteria, but can also cause fitness costs to their host.
- Using transcriptomics, researchers found that the acquisition of pOXA-48 by multidrug-resistant enterobacteria leads to both unique and shared changes in gene expression, particularly affecting a chromosomal operon in certain bacteria.
- This crosstalk is mediated by a LysR regulator encoded by the plasmid, which enhances the fitness of K. pneumoniae with pOXA-48, indicating that this mechanism may aid in the spread of carbapenem resistance in clinical environments.
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