Baseline age and time to major fracture in younger postmenopausal women.

Menopause

From the 1Department of Family Medicine, University of North Carolina, Chapel Hill, NC; 2Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC; 3Department of Biostatistics, University of North Carolina, Chapel Hill, NC; 4Department of Medicine, VA Medical Center, Minneapolis, MN; 5Department of Medicine, University of California Los Angeles, Los Angeles, CA; 6The North American Menopause Society, Mayfield Heights, OH; 7University of California at Davis, Sacramento, CA; 8University of Tennessee Health Science Center, Memphis, TN; 9Center for Health Research, Kaiser Permanente Northwest, Portland, OR;10Division of Health Policy and Management, University of Minnesota, Minneapolis, MN; and 11Fred Hutchinson Cancer Research Center, Seattle, WA.

Published: June 2015

Objective: This study aims to estimate the incidence of first hip or clinical vertebral fracture or major osteoporotic (hip, clinical vertebral, proximal humerus, or wrist) fracture in postmenopausal women undergoing their first bone mineral density (BMD) test before age 65 years.

Methods: We studied 4,068 postmenopausal women, aged 50 to 64 years without hip or clinical vertebral fracture or antifracture treatment at baseline, who were participating in the Women's Health Initiative BMD cohort study. BMD tests were performed between October 1993 and April 2005, with fracture follow-up through 2012. Outcomes were the time for 1% of women to sustain a hip or clinical vertebral fracture and the time for 3% of women to sustain a major osteoporotic fracture before initiating treatment, adjusting for clinical risk factors and accounting for competing risks. Women without osteoporosis and women with osteoporosis on their first BMD test were analyzed separately.

Results: During a maximum of 11.2 years of concurrent BMD and fracture follow-up, the adjusted estimated time for 1% of women to have a hip or clinical vertebral fracture was 12.8 years (95% CI, 8.0-20.4) for women aged 50 to 54 years without baseline osteoporosis, 7.6 years (95% CI, 4.8-12.1) for women aged 60 to 64 years without baseline osteoporosis, and 3.0 years (95% CI, 1.3-7.1) for all women aged 50 to 64 years with baseline osteoporosis. Results for major osteoporotic fracture were similar.

Conclusions: Because of very low rates of major osteoporotic fracture, postmenopausal women aged 50 to 64 years without osteoporosis on their first BMD test are unlikely to benefit from frequent rescreening before age 65 years.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411185PMC
http://dx.doi.org/10.1097/GME.0000000000000356DOI Listing

Publication Analysis

Top Keywords

hip clinical
20
clinical vertebral
20
women aged
20
aged years
20
postmenopausal women
16
vertebral fracture
16
major osteoporotic
16
women
12
bmd test
12
time women
12

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!