Background: Trichodysplasia spinulosa (TS) is a rare, striking, folliculocentric papular eruption seen exclusively in immunosuppressed patients. The eruption can be disfiguring, associated with leonine faces and alopecia. TS is caused by a polyomavirus, identified as trichodysplasia spinulosa polyomavirus (TSPyV). Few reports exist in the literature, and support for treatment options is sparse.
Method And Results: We report a patient with TS with underlying lupus nephropathy and renal transplant-associated immunosuppression. Diagnosis was confirmed by biopsy and pathognomonic histologic findings in the context of her extensive, spiculated monomorphous papules. With a biopsy-confirmed diagnosis, oral valganciclovir was prescribed, and the patient showed marked skin texture improvement and hair regrowth.
Conclusion: The continued reporting of cases of TS will improve clinical identification of this condition and provide better information regarding treatment and long-term consequences.
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Trichodysplasia spinulosa is a rare dermatological condition caused by a virus that predominantly affects immunosuppressed individuals. In this patient population, including organ transplant recipients, it is essential to maintain a high index of suspicion for possible infectious causes of persistent dermatologic conditions. Early diagnosis can facilitate treatment and help avoid disease progression and complications.
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