We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir.
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| http://dx.doi.org/10.1128/AAC.04306-14 | DOI Listing |
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Institute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 27, 12203, Berlin, Germany.
Introduction: Sinks have been introduced near patients to improve hand hygiene as part of infection prevention and control measures. However, sinks are a known reservoir for gram-negative bacterial pathogens in particular and their removal to prevent bacterial infections in intensive care patients is currently recommended by several international guidelines.
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Department of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore.
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Article Synopsis
- The article investigates a S. marcescens outbreak in a neonatal intensive care unit (NICU) and identifies the origin through a case-control study of affected and unaffected neonates.
- Whole-genome sequencing and various software were used to analyze the outbreak and determine significant risk factors, such as proximity to contaminated sinks and staff rotation patterns.
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Division for Public Health, Institute for Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, Vienna, Austria.
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