AI Article Synopsis
- Researchers analyzed the expression of ZEB1, a key protein in epithelial-mesenchymal transition (EMT), in 157 non-small cell lung carcinomas to see how it relates to E-cadherin levels.
- They found that while E-cadherin expression was low in adenocarcinomas (10%) and squamous cell carcinomas (11%), ZEB1 was rarely expressed in these cancer types.
- The study concluded that ZEB1 expression did not directly correlate with low E-cadherin levels in lung adenocarcinomas or squamous cell carcinomas, but was linked to more poorly differentiated carcinoma types, suggesting a role in advanced EMT processes.
Article Abstract
We performed an immunohistochemical analysis of the expression of zinc-finger E-box binding homeobox 1 (ZEB1), a master regulator of epithelial-mesenchymal transition (EMT), and determined its relationship with E-cadherin in 157 non-small cell lung carcinomas (93 adenocarcinomas, 36 squamous cell carcinomas, 18 large cell carcinomas, and 10 pleomorphic carcinomas). Although the expression of E-cadherin was low in the subset of adenocarcinomas (10%) and squamous cell carcinomas (11%), ZEB1 expression was only observed in one case of squamous cell carcinoma and none of the adenocarcinomas. In contrast, the low expression of E-cadherin (50% and 90%, respectively) and the positive expression of ZEB1 (11% and 50%, respectively) were more frequently observed in poorly differentiated carcinomas (large cell carcinomas and pleomorphic carcinomas). Overall, the expression of ZEB1 was inversely correlated with that of E-cadherin. Furthermore, the distribution of ZEB1-positive cancer cells was more restricted than in the area in which the expression of E-cadherin was lost, and the former was detected within the latter. We concluded that the expression of ZEB1 was not necessarily associated with the low expression of E-cadherin in lung adenocarcinomas and squamous cell carcinomas. The expression of ZEB1 correlated with an undifferentiated and/or sarcomatoid morphology that may occur in the late stage of EMT.
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