Diabetes is one of the most prevalent chronic diseases globally. In this study, major polyphenols (17.35 ± 0.93-36.66 ± 2.01 mg/g) and minor fucoxanthin (non detected 15.12 ± 0.09 mg/g) were isolated from water, ethanol, and acetone extracts (WES, EES, and AES, respectively) of Sargassum hemiphyllum. Inhibition of α-amylase, α-glucosidase, sucrose, and maltase activities and stimulation of insulin secretion was greater with AES than with WES or EES and correlated with polyphenol and fucoxanthin concentrations in extracts. Moreover, 250 μg/ml EES and AES significantly increased insulin secretion in the presence of 25 mg/ml glibenclamide to higher levels than those obtained with 50 mg/ml glibenclamide. None of the extracts exhibited cytotoxicity, exacerbated the side effects of glibenclamide, or inhibited glibenclamide-induced insulin secretion. These results suggested that the S. hemiphyllum extracts WES, EES, and AES could be used as pharmaceuticals and functional foods to reduce dosages of synthetic diabetes drugs.
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| http://dx.doi.org/10.1007/s10616-014-9745-9 | DOI Listing |
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Article Synopsis
- The study investigates the active ingredients of a widely used Chinese herbal medicine known for its central nervous system effects, comparing the effectiveness of its ethanol extracts (EES) and water extracts (WES) for the first time.
- Despite both extracts showing similar anti-depressive effects, EES contained higher levels of many components than WES, raising questions about how they achieve comparable efficacy.
- Ultimately, the research identified five key lignans that effectively target the brain, suggesting further exploration of these components could enhance understanding of the herbal medicine's active ingredients.
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