The study approaches the essential problems of chronic marginal parodontopathies in the present stage. For a more exact understanding of the intimate mechanisms which are involved in the occurrence and the development and evolution of the disease the authors start from an analysis of the health status of the marginal parodontium, to which a series of complex homeostatic processes take part, including: the progressive structuring of the marginal parodontium, neurovascular, immunological and biochemical defense mechanisms. The etiopathogeny of parodontal disease is the object of extensive investigations, and the significance of causative factors is evaluated in the light of typological understanding, of the mode of action of these factors. A dialectical unityis established between the general circumstances of the disease, and the loco-regional factors. There is a relationship between predisposition to the disease, and the pathogenetic influences which at the present time are much more diversified due to social and economic factors. An individual parodontal status develops in this way, resulting from ontogenetic accumulation, and transmissible predispositions. In the development of chronic marginal parodontitis two major circumstances are implicated, from the etiopathogenetic viewpoint: the microbial inflammation, and the totality of reactions including the immune response, and, on the other hand, occluding disorders. Changes are presented in the study, concerning biochemical constituents from the enzymatic hydrolysates of glycoproteins from the bacterial plaque. An important part of the study is concerned with results of immunological studies providing data on the presence of immune complexes in the epithelium and the chorion in various stages of parodontal disease. The gnoseological frame is defined, especially with regard to the participation of autoimmune mechanisms in the parodontal disease. In the study is also evaluated the relationship between occlusal dysfunction and the parodontal disease as a reciprocal interconditioning from which a clinical entity will result which is called "chronic marginal paradonthopathy of dystrophic type in occlusal dysfunction." From a correct understanding of the recisprocal relationship between inflammation and occlusion will result the prophylactiv attitude to parodontal disease. An important part of the study is dedicated to prophylaxis and therapy, and the most recent data from the literature and presented, as well as personal studies and researches showing the possibility for care of the individual, and the benefits of the collective health status.
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Swiss Dent J
January 2025
Klinik für Zahnerhaltung und Präventivzahnmedizin.
Periodontitis leads to a destruction of the tooth-supporting apparatus, which untreated may end up in tooth-loss. Key factor in the pathogenesis of periodontitis is the host immune response, genetic predisposition, and lifestyle factors (such as smoking, stress, and diabetes), all of which influence disease severity. Periodontitis is more common in men than women, this fact may point out that gender may have an influence on periodontitis.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
October 2024
Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Budapest, Hungary.
Aim: The aim of this study was to examine particular single-nucleotide polymorphisms (IL-1A-889 C/T - rs1800587, IL-1B +3953 C/T - rs 1143634) of interleukins 1A and 1B in the development and prognosis of medication-related osteonecrosis of the jaw.
Materials And Methods: DentiGen Parodontitis Tests were applied for collecting samples. This test is suitable for sampling oral mucosa cells in order to detect interleukins 1A and 1B single nucleotide polymorphisms (IL-1A-889, IL-1B+3953).
MMW Fortschr Med
June 2022
Lehrstuhl für Parodontologie, Fakultät für Gesundheit, Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448, Witten, Germany.
Acta Diabetol
May 2022
Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12203, Berlin, Germany.
Background: Diabetes mellitus (DM) is a risk factor for periodontitis. Data on risk-modifying factors for periodontitis in diabetes patients are limited.
Aims: We tested whether sex, age, type of diabetes, metabolic state, comorbidities, complications, measures of well-being and quality of life are predicting periodontitis in a German diabetes outpatient cohort.
Periodontitis is a complex, multifactorial disease. Multiple factors such as (epi)genetic factors, environmental factors (microbial biofilm), lifestyle (smoking, stress) and general health (diabetes mellitus) contribute to the development of periodontitis. A healthy subgingival microbiome is in balance with its host, is very stable and diverse, and keeps the host healthy.
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