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Article Synopsis
  • Alcohol consumption can lead to unpleasant hangovers and promote liver damage due to free radicals produced during ethanol breakdown.
  • This study explored the use of coral hydrate, a stable hydrogen source, as a potential treatment for alcohol intoxication in mice, showing promising results in reducing sleep time and lowering blood alcohol levels.
  • Coral hydrate also increased the expression of liver enzymes that help metabolize alcohol and reduced inflammation caused by alcohol consumption, suggesting it could be a novel therapeutic option for alcohol-related issues.
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[Determination of 8 components in healthy food for anti-hangover and hepatoprotection by high performance liquid chromatography].

Wei Sheng Yan Jiu

July 2017

Department of Laboratory Science in Public Health, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Objective: To develop a simple and sensitive high performance liquid chromatographic method for simultaneous determination of catechin hydrate, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, dihydromyricetin, glycyrrhizic acid and glycyrrhetinic acid in healthy food for anti-hangover and hepatoprotection, and compare with the capillary electrophoresis method established by our laboratory.

Methods: The samples were ultrasonically extracted by using methanol-water( 4∶ 1, V/V) for 30 minutes and then centrifuged at 10 000 r/min for 10 minutes. The supernatant was filtered and injected into the HPLC system and then separated on a C_(18) column( 5 μm × 250 mm × 4.

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Objectives: To develop a rapid method of high performance liquid chromatography coupled with variable wave length UV detection for simultaneous determination of 9 natural functional ingredients including puerarin, silymarin, quercetin hydrate, schisandrol A, curcumin, tanshinoneI, tanshinoneIIA, cryptotanshinone, and dihydrotanshinoneIin functional food for anti-hangover and hepatoprotection.

Methods: The samples were ultrasonically extracted with 90 % ethanol () and centrifuged at 10 000 r/min for 10 min prior to HPLC analysis. The nine target analytes were separated on a C8 column with gradient elution using methanol and water (The pH value was adjusted to 2.

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Ethanol metabolism produces harmful compounds that contribute to liver damage and cause an alcohol hangover. The intermediate metabolite acetaldehyde is responsible for alcohol hangover and CYP2E1-induced reactive oxygen species damage liver tissues. In this study, we examined whether ginsenoside-free molecules (GFMs) from steam-dried ginseng berries promote ethanol metabolism and scavenge free radicals by stimulating primary enzymes (alcohol dehydrogenase, aldehyde dehydrogenase, CYP2E1, and catalase) and antioxidant effects using in vitro and in vivo models.

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