AI Article Synopsis
- A new technique is introduced for reproducing liver metastasis in albino rats, minimizing stress factors like surgery and anesthesia to better mimic natural progression.
- This method enables researchers to visually track the growth of the primary tumor over time.
- It specifically demonstrates that liver metastasis occurs primarily through the bloodstream, and can aid in developing experimental treatments for this condition.
Article Abstract
A new method for reproduction of metastatic involvement of the liver in outbred albino rats is proposed. The use of the method rules out the effects of stress factors (surgical intervention, total anesthesia) on malignant tumor metastasizing, making it maximally similar to the natural process. The method allows visual evaluation of the time course of the primary tumor node growth. The metastatic involvement of the liver develops only by the most significant route, hematogenic. The method can be used for the development of experimental therapy for this condition.
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| http://dx.doi.org/10.1007/s10517-014-2664-0 | DOI Listing |
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