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Retraction: "Small Interfering RNA Effectively Inhibits Protein Expression and Negative Strand RNA Synthesis From a Full-Length Hepatitis C Virus Clone" by Prabhu, R., Vittal, P., Yin, Q.
View Article and Find Full Text PDFPlatelet C3G: a key player in vesicle exocytosis, spreading and clot retraction.
Cell Mol Life Sci
February 2024
Instituto de Biología Molecular y Celular del Cáncer (IMBCC), USAL-CSIC, Centro de Investigación del Cáncer, Campus Unamuno S/N, Salamanca, Spain.
C3G is a Rap1 GEF that plays a pivotal role in platelet-mediated processes such as angiogenesis, tumor growth, and metastasis by modulating the platelet secretome. Here, we explore the mechanisms through which C3G governs platelet secretion. For this, we utilized animal models featuring either overexpression or deletion of C3G in platelets, as well as PC12 cell clones expressing C3G mutants.
View Article and Find Full Text PDFDrug Resistance and Molecular Characteristics of Carbapenem-Resistant OXA-48-Producing Strains in Hainan, China.
Microorganisms
December 2023
Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou 570100, China.
Background: The emergence and global spread of carbapenem-resistant hypervirulent (CR-hvKP) are of great concern to health services worldwide. These β-lactamases hydrolyze almost all β-lactams, are plasmid-encoded, and are easily transferable among bacterial species. They are mostly of the KPC types in CR-hvKp.
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