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Global transcriptome changes during growth of a novel Penicillium coffeae isolate on the wheat stripe rust fungus, Puccinia striiformis f. sp. tritici.
Fungal Genet Biol
January 2025
Research School of Biology, The Australian National University, 134 Linnaeus Way, Canberra, ACT 2601, Australia. Electronic address:
Wheat stripe rust caused by the fungus Puccinia striiformis f. sp. tritici (Pst) is currently the most destructive disease of wheat.
View Article and Find Full Text PDFEpigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis.
Clin Epigenetics
January 2025
Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
Background: IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biomarkers. This study is the first to assess methylation signatures in IgG4-SC.
Results: Whole blood DNA methylation profiling and genotyping was performed in 264 individuals; 47 with IgG4-SC, 65 with PSC, 64 with ulcerative colitis (UC), and 88 healthy controls.
Brief Report: Clinical Characteristics and Outcomes of Patients With Thoracic SMARCA4-Deficient Undifferentiated Tumors.
JTO Clin Res Rep
January 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Introduction: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs) are a recently defined group of aggressive cancers in which the effectiveness of standard treatments for lung cancer is unknown.
Methods: We collected clinical, pathologic, and demographic variables from five institutions for patients whose tumors met criteria for SMARCA4-UTs (undifferentiated phenotype and loss of SMARCA4 (BRG1) by immunohistochemistry).
Results: We identified 92 patients with SMARCA4-UTs; 58 (63%) had stage IV disease at diagnosis and 16 (17%) developed recurrent or metastatic disease after initial diagnosis.
Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure-informed normative tractometry.
Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Introduction: Diffusion-weighted magnetic resonance imaging (dMRI) is sensitive to the microstructural properties of brain tissues and shows great promise in detecting the effects of degenerative diseases. However, many approaches analyze single measures averaged over regions of interest without considering the underlying fiber geometry.
Methods: We propose a novel macrostructure-informed normative tractometry (MINT) framework to investigate how white matter (WM) microstructure and macrostructure are jointly altered in mild cognitive impairment (MCI) and dementia.
Haven for Hope: A Transformational Campus Model to Address Homelessness.
Community Ment Health J
December 2024
Haven for Hope, San Antonio, TX, USA.
Haven for Hope is a 501(c)(3) nonprofit organization that has been rarely described in the research literature but has become nationally known for its comprehensive homeless response system in San Antonio, Texas. Haven for Hope operates a 22-acre campus that includes a Transformational Campus and a Courtyard that serves over 9,000 clients annually, including chronically homeless individuals, veterans, children, and families. Haven for Hope offers a "one-stop" design that allows dozens of community partner organizations to provide housing, meals, healthcare, job training, education, childcare, and pet services on-site.
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