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| http://dx.doi.org/10.3389/fpsyg.2014.01138 | DOI Listing |
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Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
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Department of Physiology and Pathophysiology, School of Basic Medicine, Dali University, Dali, 671003, China.
The aim of this study was to explore the role of the ZnT9 protein in obesity-induced sperm maturation disorders in men. We generated a mouse model of obesity-induced weak spermatogenesis via a high-fat diet (HFD) for 10 weeks. In addition to the HFD, a 5-week intervention of salubrinal (SAL) (an inhibitor of endoplasmic reticulum stress) (1 mg/kg/day), ZnSO (15 mg/kg/day), and their combination was started at week 6, after which sperm viability and epididymal tissue damage were assessed.
View Article and Find Full Text PDFPrecision in Stroke Care: A Novel Model for Predicting Functional Independence in Urgent Carotid Intervention Patients.
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- The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA.
Background: Stroke requires timely intervention, with carotid endarterectomy (CEA) and carotid artery stenting (CAS) increasingly used in select acute carotid-related stroke patients. We aimed to build a model to predict neurologic functional independence (modified Rankin scale, mRS ≤ 2) in this high-risk group.
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Associations Between Frailty and Risk of All-Cause and Cardiovascular Mortality in Patients with Prediabetes: A Population-Based Study.
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Department of Geriatric Medicine, Chongqing Seventh People's Hospital, Chongqing, 400054, People's Republic of China.
Objective: Diabetes is a well-known risk factor for frailty that has been associated with adverse prognosis. However, the association of frailty with all-cause and cardiovascular disease (CVD) mortality in patients with prediabetes has not been thoroughly explored.
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Disruptive multiple cell death pathways of bisphenol-A.
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Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, India.
Endocrine-disrupting chemicals (EDCs) significantly contribute to health issues by interfering with hormonal functions. Bisphenol A (BPA), a prominent EDC, is extensively utilized as a monomer and plasticizer in producing polycarbonate plastic and epoxy resins, making it one of the highest-demanded chemicals in commercial use. This is the major component used in plastic products, including bottles, containers, storage items, and food serving ware.
View Article and Find Full Text PDFPotential of emodepside for vector-borne disease control.
Malar J
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Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Background: Emodepside is an anthelmintic used in veterinary medicine that is currently under investigation in human clinical trials for the treatment of soil-transmitted helminths and possibly Onchocerca volvulus. Emodepside targets the calcium-activated voltage-gated potassium slowpoke 1 (SLO-1) channels of presynaptic nerves of pharynx and body wall muscle cells of nematodes leading to paralysis, reduced locomotion and egg laying, starvation, and death. Emodepside also has activity against Drosophila melanogaster SLO-1 channels.
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