Covalent or Noncovalent? Systematic investigation of polymeric binders incorporating Meldrum's acid reveals most critical binder properties for silicon -anodes in lithium ion batteries, that is self-healing effect facilitated by a series of noncovalent interactions.
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http://dx.doi.org/10.1002/adma.201402950 | DOI Listing |
PLoS One
January 2025
Manchester Cancer Research Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Non-covalent protein-protein interactions are one of the most fundamental building blocks in cellular signalling pathways. Despite this, they have been historically hard to identify using conventional methods due to their often weak and transient nature. Using genetic code expansion and incorporation of commercially available unnatural amino acids, we have developed a highly accessible method whereby interactions between biotinylated ubiquitin-like protein (UBL) probes and their binding partners can be stabilised using ultraviolet (UV) light-induced crosslinks.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Civil Engineering Program, Universidad de Cartagena, Cartagena 130015, Colombia.
Artificial sand cementation improves stability, stiffness, and mechanical strength, making it a critical process in geotechnical applications. This study analyzes the capability of the porosity-water/binding agent index (ηCw/Biv) to predict cemented sands' unconfined compressive strength (qu) and stiffness (Go). Four Colombian sands, i.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
College of Environmental Science and Engineering, Nankai University, 38 Tongyan Road, Jinnan District, 300350 Tianjin, China.
Reclaimed asphalt pavement (RAP) is a widely used end-of-life (EoL) material in asphalt pavements to increase the material circularity. However, the performance loss due to using RAP in the asphalt binder layer often requires a thicker layer, leading to additional material usage, energy consumption, and transportation effort. In this study, we developed a parametric and probabilistic life cycle assessment (LCA) framework to robustly compare various pavement designs incorporating recycled materials.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, 20 N Pine Street, Baltimore, Maryland, 21201, USA.
Dosage forms containing Ivermectin (IVER) and Praziquantel (PRAZ) are important combination drug products in animal health. Understanding the relationship between products with differing in vitro release characteristics and bioequivalence could facilitate generics. The goal of this study was to create granulations for each active ingredient, with similar release mechanisms, but substantially different in vitro release rates, and then compressing these granulations into tablets with differing release rates.
View Article and Find Full Text PDFKidney360
January 2025
Unicycive Therapeutics, Los Altos, CA, United States.
Background: This study evaluated the combined effects of oxylanthanum carbonate (OLC), an investigational phosphate binder, and tenapanor, an approved sodium/hydrogen exchanger 3 (NHE3) inhibitor that reduces paracellular phosphate absorption, on urinary phosphate excretion in rats on a high phosphorus diet.
Methods: Sixty-four male Sprague Dawley rats were randomized into eight groups: vehicle; tenapanor (0.15 mg/kg) only; OLC (0.
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