The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of H. inuloides could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with in vivo systems will afford information about H. inuloides beneficial and detrimental properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206868 | PMC |
| http://dx.doi.org/10.1038/srep06743 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In Saccharomyces cerevisiae cells, the bulk of mitochondrial DNA (mtDNA) replication is mediated by the replicative high-fidelity DNA polymerase γ. However, upon UV irradiation low-fidelity translesion polymerases: Polη, Polζ and Rev1, participate in an error-free replicative bypass of UV-induced lesions in mtDNA. We analysed how translesion polymerases could function in mitochondria.
View Article and Find Full Text PDFRevealing the nutritious treasures: an extensive investigation of health benefits of cultured dairy foods.
Arch Microbiol
December 2024
Centre for Research in Environment, Sustainability Advocacy and Climate CHange (REACH), Directorate of Research, SRM Institute of Science and Technology, Kattankulathur 603 203, Chengalpattu District, Tamil Nadu, India.
Cultured milk products including yogurt, buttermilk, and lassi have made their way into South Asian cuisine for hundreds of years and are extraordinarily beneficial to human health. With a study background on lactic acid bacteria (LAB), these products are scientifically proved to aid in strengthening the immune system, for their anti-mutagenic effects, suitability for those who are lactose intolerant, and for protection against cancer, osteoporosis, and gut disorders. As of now, no scientific attention has been given to the microbial diversity of cultured milk products despite its prominent production and importance in the culture.
View Article and Find Full Text PDFAntioxidant, antimutagenic, and hypoglycemic properties of flours by different parts of marolo (Annona crassiflora Mart.) seeds: Film and almond.
Food Res Int
November 2024
Programa de Pós-graduação em Nutrição e Longevidade, Universidade Federal de Alfenas, Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, MG, 37130-001, Brasil; Laboratório de Nutrição Experimental, Faculdade de Nutrição, Universidade Federal de Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, MG, 37130-001, Brasil. Electronic address:
The biological effects of marolo (Annona crassiflora Mart.) seed byproducts, a native fruit of Brazilian Cerrado, have not been extensively studied. We evaluated the chemopreventive potential of marolo seed almond flour (MSAF) and marolo seed film flour (MSFF) and correlated the results obtained with the antioxidant capacity presented by the seed.
View Article and Find Full Text PDFSystematic Characterisation of the Fragmentation of Flavonoids Using High-Resolution Accurate Mass Electrospray Tandem Mass Spectrometry.
Molecules
November 2024
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Flavonoids are a class of polyphenolic secondary metabolites found in plants. Due to their ubiquity in our daily dietary intake and their major anti-oxidative, anti-inflammatory and anti-mutagenic activities, they have been a major focus of wide-ranging research for the past two decades. Mass spectrometry combined with liquid chromatography is one of the most popular techniques for the analysis of flavonoids.
View Article and Find Full Text PDFHeterocyclic phytometabolites formononetin and arbutin prevent oxidative and alkylation-induced mutagenicity.
Toxicol Rep
December 2024
Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Phenolic phytometabolites are promising bioactive compounds for management of genomic instability related diseases. Formononetin (FMN) and arbutin (ARB) are found in several plant sources. Our goal was to investigate the safety and efficacy of FMN and ARB using both standardized and alternative toxicogenetic methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!