The results of the clinico-genealogical investigation of patients with mild haemophilia A in a large azerbaijanian highly inbred kindred (446 members in VII generations) are presented. Some peculiarities of the disease segregation are discussed. The prevalence of the haemophilia A in the population examined was estimated as about 1:440.
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The authors specified the prevalence of syncopal states in the representative sample of 2309 schoolchildren from the city of Kazan, as well as hereditary factors in the genesis of neurogenic syncopes basing on the clinico-genealogical analysis of 115 families. 91.4% of the syncopal conditions were considered to be neurogenic syncopes (populational frequency is 6.
View Article and Find Full Text PDFThe paper presents a clinical and genealogical characterization of 50 probands suffering from coronary heart disease concurrent with various lipid metabolic disturbances and 211 first-degree relatives whose data have been obtained from the probands' histories while making up their pedigrees. The prevalence of atherosclerosis among the first-degree relatives has been demonstrated to be related to the nature of lipid metabolic disturbances in a proband. Some dyslipoproteinemias in the proband have been characterized by early onset of coronary heart disease, stroke, and their grave course in close relatives.
View Article and Find Full Text PDFThe families of 128 probands with Alzheimer's disease (AD) and senile dementia (SD) were studied. Genetical and mathematical analyses were employed to estimate the clinico-genealogical findings. The genetic factors were found to be likely to make some contribution to the origin of Alzheimer-type dementia (ATD).
View Article and Find Full Text PDF[Clinico-genealogical study of Alzheimer's disease].
Zh Nevropatol Psikhiatr Im S S Korsakova
February 1991
A ++clinico-genealogical study of Alzheimer's disease (AD) was carried out on a material of 64 families of AD probands. Among the families examined, 21 families with hereditary aggravation, 17 sporadic and 26 conventionally sporadic families were distinguished. Risk for AD was established for relatives of the first degree kinship and a possible type of AD inheritance was defined.
View Article and Find Full Text PDF[Clinico-genealogical and phenotypic characteristics of patients with late sequelae of closed cranio-cerebral injuries].
Zh Nevropatol Psikhiatr Im S S Korsakova
November 1990
As many as 100 patients with late sequelae of closed craniocerebral injuries (CCCI) and 50 healthy persons underwent a clinico-genealogical and phenotypic analysis. Multifactorial diseases (in particular essential hypertension and other cardiovascular diseases) which correlate with the clinical features of late sequelae of CCCI were noted to occur in the patients' pedigree significantly more often as compared to normal persons. The patients manifest a high frequency of the stigmas of dysembryogenesis.
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