A novel "turn-on" phosphorescent chemodosimeter based on a cyclometalated Ir(III) complex has been designed and synthesized, which displays high selectivity and sensitivity toward Hg(2+) in aqueous media with a broad pH range of 4-10. Furthermore, by time-resolved photoluminescence techniques, some interferences from the short-lived background fluorescence can be eliminated effectively and the signal-to-noise ratio of the emission detection can be improved distinctly by using the chemodosimeter. Finally, the chemodosimeter can be used to monitor Hg(2+) effectively in living cells by confocal luminescence imaging.
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Ir(iii) complex-based phosphorescence and electrochemiluminescence chemodosimetric probes for Hg(ii) ions with high selectivity and sensitivity.
Dalton Trans
March 2018
Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-747, Korea.
Mercury, one of the most prevalent toxic metal elements, poses severe risks to human health and the environment. Several molecular probes have been developed for colorimetric and fluorometric detection of Hg(ii) ions. Nevertheless, development of a rapid, selective, and sensitive probe for Hg(ii) ions remains important.
View Article and Find Full Text PDFDesign and application of a water-soluble phosphorescent Ru(ii) complex as turn-on sensing material for Hg.
J Mater Chem B
August 2015
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Special Function Materials and Structure Design, Ministry of Education, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
A novel phosphorescent chemodosimeter material Ruphen-1 based on a Ru(ii) complex has been designed and developed by introducing Hg-promoted desulfurization and intramolecular cyclic guanylation of thiourea reaction into the luminophor. Ruphen-1 not only possessed a longer excitation wavelength, large Stokes shift and good water solubility, but also exhibited high selectivity and sensitivity only toward Hg with a rapid turn-on phosphorescence response in an aqueous system over a wide range of pH (4.0-9.
View Article and Find Full Text PDFRatiometric iridium(III) complex-based phosphorescent chemodosimeter for Hg(2+) applicable in time-resolved luminescence assay and live cell imaging.
Anal Chem
March 2015
†Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
A novel iridium(III) complex-based probe Ir4-1 has been designed and synthesized conveniently by incorporating the chemodosimeter into phosphorescent luminophor, which displayed ratiometric luminescence change from yellowish-green to reddish-yellow only toward Hg(2+) ions in aqueous media via desulfurization and intramolecular cyclization with a broad pH range of 5-10. The phosphorescent chemodosimeter could eliminate effectively the signal interference from the short-lived fluorescent background, and the signal-to-noise ratio of the detection was improved distinctly by using time-resolved photoluminescence technique. Furthermore, the mechanism of phosphoresce change of the chemodosimeter was analyzed in detail by time-dependent density functional theory (TD-DFT) calculations, and the probe with long-wavelength emission could be applied to label cells and monitor intracellular Hg(2+) effectively by luminescence ratio imaging.
View Article and Find Full Text PDFExploitation and application of a highly sensitive Ru(II) complex-based phosphorescent chemodosimeter for Hg2+ in aqueous solutions and living cells.
ACS Appl Mater Interfaces
February 2015
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering and ‡School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
A novel Ru(II) complex-based phosphorescent probe Rubpy-1 was designed and synthesized conveniently by incorporating of chemodosimeter into the luminophor, which exhibits good water solubility, longer excitation wavelength, and rapid turn-on phosphorescent response only toward Hg(2+) in aqueous system under physiological pH. The spectral response mechanism and Hg(2+)-promoted structure change of the chemodosimeter were analyzed in detail by theoretical calculations and electrospray ionization mass spectrometry. When time-resolved photoluminescence techniques were used, the Rubpy-1 could eliminate effectively the signal interference from the short-lived background fluorescence in complicated media, accompanied by the significant improvement of the signal-to-noise ratio and the accuracy of the detection.
View Article and Find Full Text PDFTurn-on phosphorescent chemodosimeter for Hg2+ based on a cyclometalated Ir(III) complex and its application in time-resolved luminescence assays and live cell imaging.
Inorg Chem
November 2014
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, and ‡School of Life Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China.
A novel "turn-on" phosphorescent chemodosimeter based on a cyclometalated Ir(III) complex has been designed and synthesized, which displays high selectivity and sensitivity toward Hg(2+) in aqueous media with a broad pH range of 4-10. Furthermore, by time-resolved photoluminescence techniques, some interferences from the short-lived background fluorescence can be eliminated effectively and the signal-to-noise ratio of the emission detection can be improved distinctly by using the chemodosimeter. Finally, the chemodosimeter can be used to monitor Hg(2+) effectively in living cells by confocal luminescence imaging.
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