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Metabolic Activation and Cytotoxicity of Donepezil Induced by CYP3A4.
Chem Res Toxicol
December 2024
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.
Donepezil (DNP) is a selective cholinesterase inhibitor widely used for the therapy of Alzheimer's disease. Instances of liver injury correlated with DNP treatment have been reported, yet the underlying hepatotoxic mechanism remains to be elucidated. This study aimed to explore the contribution of metabolic activation to the hepatotoxicity of DNP.
View Article and Find Full Text PDFDonepezil-induced hepatotoxicity in an elderly adult taking fluoxetine.
J Am Geriatr Soc
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