AI Article Synopsis
- Ganoderma lucidum, also known as Ling Zhi, has been used for therapeutic purposes in various Asian countries for over 2,000 years and is studied for its DNA protecting abilities in human lymphocytes.
- The study involved isolating beta glucan (BG) from the fungus and evaluating its properties using various spectroscopy techniques, as well as its radioprotective effects on lymphocytes exposed to gamma radiation.
- Results showed that BG significantly reduced DNA damage, indicating its potential for preventing radiation-induced cellular damage due to its antioxidant properties and ability to repair DNA.
Article Abstract
Background: Ganoderma lucidum (Ling Zhi), a basidiomycete white rot macrofungus has been used extensively for therapeutic use in China, Japan, Korea and other Asian countries for 2,000 years. The present study is an attempt to investigate its DNA protecting property in human lymphocytes.
Materials And Methods: Beta glucan (BG) was isolated by standard procedure and the structure and composition were studied by infrared radiation (IR) and nuclear magnetic resonance (NMR) spectroscopy, gel filtration chromatography and paper chromatography. The radioprotective properties of BG isolated from the macro fungi Ganoderma lucidum was assessed by single cell gel electrophoresis (comet assay). Human lymphocytes were exposed to 0, 1, 2 and 4 Gy gamma radiation in the presence and absence of BG.
Results: The comet parameters were reduced by BG. The results indicate that the BG of G. lucidum possessed significant radioprotective activity with DNA repairing ability and antioxidant activity as the suggestive mechanism.
Conclusions: The findings suggest the potential use of this mushroom for the prevention of radiation induced cellular damages.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202477 | PMC |
| http://dx.doi.org/10.3978/j.issn.2305-5839.2014.02.02 | DOI Listing |
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