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The Genetic and Epigenetic Arms of Human Ageing and Longevity.
Biology (Basel)
January 2025
Molecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, Italy.
This proposed review aims to shed light on the major genetic and epigenetic contributions to the ageing process and longevity of individuals. In this context, we summarize the state of knowledge on the most important longevity and ageing genetic variants, and their interactions with the environment, in achieving a healthy lifespan. We also explore the contribution of lifestyle and the influence of non-heritable environmental factors on ageing (i.
View Article and Find Full Text PDFRethinking cancer evolution: from genetic mutations to complex information systems in tumor reversion.
Evol Med Public Health
December 2024
Department of Surgery, University of Health Sciences, Ankara City Hospital, Cankaya, Ankara, Turkey.
Cancer research has historically focused on the somatic mutation theory, viewing cancer as a consequence of genetic mutations. However, this perspective has limitations in explaining phenomena like tumor reversion and cancer heterogeneity. This paper introduces an alternative approach: viewing cancer as a complex information-processing system shaped by its microenvironment.
View Article and Find Full Text PDFRethinking love, independence, and speciesism in assistance dog discourse.
Front Sociol
January 2025
Section Sociology of Social Differentiation and Socio-culture, Department of Social Work and Social Welfare, Faculty of Human Sciences, University of Kassel, Kassel, Germany.
This paper challenges the prevailing belief that assistance dogs inherently love their roles, arguing that the notion of "unconditional love" in discourses on assistance dog perpetuates a human-centric perspective and reinforces speciesism. It emphasizes the importance of recognizing the affective experiences of these working animals and of acknowledging the interdependence between people with disabilities and assistance dogs. The paper has four main objectives: (1) critiquing the concept of unconditional love attributed to assistance dogs, (2) recognizing the physical and affective labor of assistance dogs, (3) highlighting the importance of interdependence over independence, and (4) exploring the intersections of ableism and speciesism in the context of assistance dogs.
View Article and Find Full Text PDFDimples as Desired Outcomes: Rethinking Their Role in Thread Lifting Procedures.
Plast Reconstr Surg Glob Open
January 2025
Solitaire Aesthetics, Singapore.
Facial thread lifts, known for being minimally invasive with quick results, can sometimes lead to dimpling. A case report of a 35-year-old Asian man who developed a pleasing unilateral dimple after a thread lift highlights the potential for intentional dimple creation through this method. With surgical dimple creation in demand, as dimples symbolize good luck in Chinese culture and beauty in Arabic traditions, thread lifts may offer a less invasive alternative for those seeking dimples without surgery.
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