Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nrneurol.2014.195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Progress of Chinese Medicine in Regulating Microglial Polarization against Alzheimer's Disease.
Am J Chin Med
December 2024
Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P. R. China.
Alzheimer's disease (AD), the predominant form of dementia, is a neurodegenerative disorder of the central nervous system (CNS) characterized by a subtle onset and a spectrum of cognitive and functional declines. The clinical manifestation of AD encompasses memory deficits, cognitive deterioration, and behavioral disturbances, culminating in a severe impairment of daily living skills. Despite its high prevalence, accounting for 60-70% of all dementia cases, there remains an absence of curative therapeutics.
View Article and Find Full Text PDFCorrigendum to "Effectiveness of nurse-delivered stepwise swallowing training on dysphagia in patients with Alzheimer's disease: A multi-center randomized controlled trial" [Int. J. Nurs. Stud. 150 (2024) 104649].
Int J Nurs Stud
December 2024
Geriatric Neuroscience Center, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Department of Nursing, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:
The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway.
Int Immunopharmacol
December 2024
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, China; Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-class Construction Interdiscipline, China. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta-amyloid (Aβ) peptides. Microglia-mediated neuroinflammation is one of the primary contributors to the pathogenesis of AD. Withanolides, the main constituents in the leaves of Datura stramonium L.
View Article and Find Full Text PDFRobust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy.
EBioMedicine
December 2024
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Background: Perivascular spaces (PVS) on brain MRI are surrogates for small parenchymal blood vessels and their perivascular compartment, and may relate to brain health. However, it is unknown whether PVS can predict dementia risk and brain atrophy trajectories in participants without dementia, as longitudinal studies on PVS are scarce and current methods for PVS assessment lack robustness and inter-scanner reproducibility.
Methods: We developed a robust algorithm to automatically assess PVS count and size on clinical MRI, and investigated 1) their relationship with dementia risk and brain atrophy in participants without dementia, 2) their longitudinal evolution, and 3) their potential use as a screening tool in simulated clinical trials.
A novel Alzheimer detection rapid-testing low-cost technique by a gate engineered gate stack dual-gate FET device.
Talanta
December 2024
Nextgen Adaptive Systems Group, Department of Electrical Engineering, National Institute of Technology Patna, Bihar, India. Electronic address:
This study explores a quick, low-cost method to detect Alzheimer's disease (AD) by evaluating the accomplishment of a Gate-Stack (GS) Field Effect Transistor (FET). We investigate Single-Metal (SM), Dual-Metal (DM), and Tri-Metal Double Gate (DG) configurations, where cavities have been created by etching the oxide layer underneath the gate to immobilize grey matter samples collected through Solid-phase microextraction (SPME). Healthy and AD-affected grey matter have different dielectric characteristics at high frequencies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!