AI Article Synopsis
- Duodenal atresia is a rare birth defect found in about 1 in 10,000 infants, often associated with trisomy 21.
- Two siblings were born with this condition, alongside their father who also had it, suggesting a potential genetic link.
- Recurrent cases should be evaluated for possible autosomal dominant or recessive inheritance patterns, especially if identified before birth.
Article Abstract
Background: Duodenal atresia is a rare disorder occurring in 1 in 10,000 live births. Duodenal atresia is associated with trisomy 21: 5-15% of trisomy 21 cases have duodenal atresia and 30% of duodenal atresia cases are associated with trisomy 21. Some cases of duodenal atresia may be recurrent.
Case: Two siblings were born with duodenal atresia but no other anomalies. The father of the siblings also had isolated congenital duodenal atresia.
Conclusion: Recurrent duodenal atresia should be considered when the condition is discovered prenatally. The etiology may be autosomal dominant inheritance, as with Feingold syndrome, or autosomal recessive inheritance.
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