Many real world optimization problems involve uncertainties. A solution for such a problem is expected to be robust to these uncertainties. Commonly, robustness is attained by choosing the solution's parameters such that the solution's performance is less influenced by negative effects of the uncertain parameters' variations. This robustness may be viewed as a passive robustness, because once the solution's parameters are chosen, the robustness is inherent in the solution and no further action, to suppress the effect of uncertainties, is expected. However, it is acknowledged that enhanced robustness comes at the expense of peak performances. In this paper, active robust optimization is presented as a new robust optimization approach. It considers products that are able to adapt to environmental changes. The enhanced robustness of these solutions is attained by adaptation, which reduces the loss in performance due to environmental changes. A new optimization problem named active robust optimization problem is formulated. The problem amalgamates robust optimization with dynamic optimization to evaluate the performance of a candidate solution, while considering possible environmental conditions. The adaptation's influence on the solution's performance and cost is considered as well. Hence, the problem is formulated as a multiobjective problem that simultaneously aims at low costs and high performance. Since these goals are commonly in conflict, the solution is a set of optimal adaptive solutions. An evolutionary algorithm is proposed in order to evolve this set. An example of optimizing an adaptive optical table is provided. It is shown that an adaptive product, which is an outcome of the suggested approach, may be superior to an equivalent product that is not adaptive.
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http://dx.doi.org/10.1109/TCYB.2014.2304475 | DOI Listing |
J Integr Plant Biol
January 2025
State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences (ICS), Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100081, China.
The development of a single and multiplex gene editing system is highly desirable for either functional genomics or pyramiding beneficial alleles in crop improvement. CRISPR/Cas12i3, which belongs to the Class II Type V-I Cas system, has attracted extensive attention recently due to its smaller protein size and less restricted canonical "TTN" protospacer adjacent motif (PAM). However, due to its relatively lower editing efficiency, Cas12i3-mediated multiplex gene editing has not yet been documented in plants.
View Article and Find Full Text PDFMol Divers
January 2025
Center of Bioinformatics, College of Life Sciences, Northwest Agriculture and Forestry University, Yangling, 712100, Shaanxi, China.
Melanoma, a highly aggressive skin cancer, remains a significant cause of mortality despite advancements in therapeutic strategies. There is an urgent demand for developing vaccines that can elicit strong and comprehensive immune responses against this malignancy. Achieving this goal is crucial to enhance the efficacy of immunological defense mechanisms in combating this disease.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Electrical and Computer Engineering, Duke University, Durham, North Carolina 27704, USA.
This paper addresses achieving the high time-bandwidth product necessary for low signal-to-noise ratio (SNR) target detection and localization in complex multipath environments. Time bandwidth product is often limited by dynamic environments and platform maneuvers. This paper introduces data-driven wideband focusing methods for passive sonar that optimize parameterized unitary matrices to align signal subspaces across the frequency band without relying on wave propagation models which are subject to mismatch in complex multipath environments.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Laboratório de Processos Eletroquímicos e Corrosão-ELETROCORR, Departamento de Metalurgia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, 91501-970 Porto Alegre, Brazil.
This study presents an innovative approach to creating antibacterial aluminum surfaces by combining the antibacterial properties of silver nanoparticles (Ag NPs) with the nanoarchitecture of anodized aluminum oxide in one step. An Al-Ag alloy containing 10 wt % Ag was synthesized and anodized in 0.3 M oxalic acid.
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January 2025
Department of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL, United States.
Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.
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