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Background: XPro1595 (XPro) is a brain-penetrant, recombinant protein variant of human tumor necrosis factor (TNF) rationally designed to selectively neutralize only the soluble, pro-inflammatory form of the cytokine (solTNF). An unbiased proteomic analysis of CSF samples from an open-label, phase-1b study (NCT03943264) in patients with Alzheimer's disease (AD) was conducted to assess for pharmacodynamic activity and disease-specific target engagement.
Method: Patients with AD (n = 20) were treated for 12-weeks with one of three doses of XPro: 0.
Background: Homozygosity for the rare APOE3-Christchurch (APOE3Ch) variant, encoding for apoE3-R136S (apoE3-Ch), was linked to resistance against an aggressive form of familial Alzheimer's disease (AD). Carrying two copies of APOE3Ch was sufficient to delay autosomal AD onset by 30 years. This remarkable protective effect makes it a strong candidate for uncovering new therapies against AD.
View Article and Find Full Text PDFEffect of Fold-Promoting Mutation and Signal Peptide Screening on Recombinant Glucan 1,4-Alpha-maltohydrolase Secretion in Pichia pastoris.
Appl Biochem Biotechnol
January 2025
College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China.
Glucan 1,4-alpha-maltohydrolase (3.2.1.
View Article and Find Full Text PDFRecombinant Porcine FGF1 Promotes Muscle Stem Cell Proliferation and Mitochondrial Function for Cultured Meat Production.
J Agric Food Chem
January 2025
Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Cultured meat is an emerging technology with the potential to meet future protein demands while addressing the challenges associated with traditional livestock farming. The production of cultured meat requires efficient, animal component-free systems for muscle stem cell (MuSC) expansion. Fibroblast growth factor 1 (FGF1) is a critical growth factor that regulates the MuSC function.
View Article and Find Full Text PDFExpression of Recombinant Clostridial Neurotoxin by .
Microorganisms
December 2024
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Tetanus neurotoxins (TeNT) and botulinum neurotoxins (BoNTs) are closely related ~150 kDa protein toxins that together comprise the group of clostridial neurotoxins (CNTs) expressed by various species of . While TeNT is expressed as a single polypeptide, BoNTs are always produced alongside multiple non-toxic proteins that form a stabilizing complex with BoNT and are encoded in a conserved toxin gene cluster. It is unknown how evolved without a similar gene cluster and why complex-free TeNT is secreted as a stable and soluble protein by , whereas complexing proteins appear to be essential for BoNT stability in culture supernatants of .
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