Medico-historical overview and histopathological comments about a hyalinizing trabecular tumor case of thyroid gland.

Introduction: Hyalinizing Trabecular Tumor (HTT) of the thyroid gland is a rare and controversial tumor, whose rigorous identification is extremely important due to the difficulty of establishing a correct diagnosis using only the routine histological stains (Hematoxylin-Eosin, Periodic Acid-Schiff, van Gieson, etc.). Using only usual stains, difficult problems of differential diagnosis arise. In this paper, we report a clinically unexpected case of HTT, the first in Romania, whose diagnosis has been established only by immunohistochemistry reactions.

Materials, Methods And Results: In assessing a case with nodular goiter for diagnose purpose, we have found a nodule difficult to diagnose. We have been determined to appeal to some additional immunohistochemical techniques.

Conclusions: According to the immunohistochemistry reactions made, we found that particularly the Ki-67 immunohistochemical stain is obvious indispensable in establishing the diagnosis of HTT. We present also a medico-historical overview concerning some first descriptions of this rare entity. There are also mentioned some data regarding the behavior of this rare thyroid tumor.