AI Article Synopsis
- Brazil has a surplus of sucrose from sugarcane, enabling the production of high-value products like gluconic acid (GA) through multi-enzyme conversion using invertase, glucose oxidase, and catalase.
- The study investigates the optimal conditions for GA production in an airlift reactor, focusing on temperature and pH, and determines that 40 °C and pH 6.0 are ideal for enzyme activity and stability.
- Under these conditions, the maximum GA yield is reached within 3.8 hours, achieving full conversion of sucrose and glucose, with a productivity of about 7.0 g L(-1) h(-1).
Article Abstract
Sucrose from sugarcane is produced in abundance in Brazil, which provides an opportunity to manufacture other high-value products. Gluconic acid (GA) can be produced by multi-enzyme conversion of sucrose using the enzymes invertase, glucose oxidase, and catalase. In this process, one of the byproducts is fructose, which has many commercial applications. This work concerns the batch mode production of GA in an airlift reactor fed with sucrose as substrate. Evaluation was made of the influence of temperature and pH, as well as the thermal stability of the enzymes. Operational conditions of 40 °C and pH 6.0 were selected, based on the enzymatic activity profiles and the thermal stabilities. Under these conditions, the experimental data could be accurately described by kinetic models. The maximum yield of GA was achieved within 3.8 h, with total conversion of sucrose and glucose and a volumetric productivity of around 7.0 g L(-1) h(-1).
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| http://dx.doi.org/10.1007/s00449-014-1306-2 | DOI Listing |
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Article Synopsis
- Researchers have developed glucose-responsive insulin release systems, using chitosan-based three-compartment microspheres (TCMs) to achieve prolonged insulin delivery.
- The TCMs release insulin based on blood glucose levels, as glucose generates gluconic acid, which degrades chitosan and triggers insulin release from compartments with varying concentrations.
- In tests, TCMs showed longer-lasting insulin release and effective blood glucose regulation in diabetic cell models, demonstrating promising potential for diabetes treatment and insulin research.
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