Background: Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases.
Main Observations: Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological examination revealed the presence of a mast cell population in the papillary and reticular dermis combined with overlying melanocytic nevi. The re-evaluation of a melanoma removed three years before revealed the presence of the same pathological features. Immunohistochemical assays showed a strong positivity to Giemsa, Toluidine blue and CD-117 in the mast cells, while a S-100 reaction was observed in the melanocytic population.
Conclusions: We discuss possible pathogenetic linkage between cutaneous mastocytosis and melanoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195503 | PMC |
| http://dx.doi.org/10.3315/jdcr.2014.1179 | DOI Listing |
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