AI Article Synopsis
- FEMY-R7, a combination of fucoidan and evening primrose extract, was tested for its ability to eliminate H. pylori in both mice and humans.
- Male mice were infected with H. pylori and treated with FEMY-R7, resulting in a significant reduction in urease-positive reactivity.
- In a human clinical study, participants treated with FEMY-R7 showed significant decreases in urea breath test results and serum pepsinogen levels, indicating successful H. pylori elimination and improved gastric function.
Article Abstract
Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188832 | PMC |
| http://dx.doi.org/10.5625/lar.2014.30.3.131 | DOI Listing |
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Erratum: In vitro and in vivo anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract.
Lab Anim Res
June 2015
College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
[This corrects the article on p. 28 in vol. 30, PMID: 24707302.
View Article and Find Full Text PDFComparative analysis of anti-Helicobacter pylori activities of FEMY-R7 composed of Laminaria japonica and Oenothera biennis extracts in mice and humans.
Lab Anim Res
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College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Helicobacter pylori-eliminating effects of FEMY-R7, composed of Laminaria japonica and Oenothera biennis extracts, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with total 20, 64 or 200 mg/kg/day FEMY-R7 for 2 weeks. In Campylobcter-like organism (CLO)-detection tests on gastric mucosa and feces, FEMY-R7 reduced the urease-positive reactivity in a dose-dependent manner; i.
View Article and Find Full Text PDFAnti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans.
Lab Anim Res
September 2014
College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Article Synopsis
- FEMY-R7, a combination of fucoidan and evening primrose extract, was tested for its ability to eliminate H. pylori in both mice and humans.
- Male mice were infected with H. pylori and treated with FEMY-R7, resulting in a significant reduction in urease-positive reactivity.
- In a human clinical study, participants treated with FEMY-R7 showed significant decreases in urea breath test results and serum pepsinogen levels, indicating successful H. pylori elimination and improved gastric function.
In vitro and in vivo anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract.
Lab Anim Res
March 2014
College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Effects of FEMY-R7, composed of fucoidan and evening primrose extract, on the bacterial growth and intragastric infection of Helicobacter pylori as well as gastric secretion were investigated in comparison with a proton-pump inhibitor pantoprazole. For in vitro anti-bacterial activity test, H. pylori (1×10(8) CFU/mL) was incubated with a serially-diluted FEMY-R7 for 3 days.
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