The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing γ-lactones 3 to be directly obtained with high regioselectivities and yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol502855q | DOI Listing |
Publication Analysis
Top Keywords
catalytic approach
8
approach metal-free
4
metal-free reaction
4
reaction epoxides
4
epoxides ketene
4
ketene silyl
4
silyl acetals
4
acetals accessing
4
accessing γ-lactones
4
γ-lactones catalytic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!