AI Article Synopsis
- Dopamine neurons play a significant role in fear processes, but their signaling during active fear conditioning is not well understood.
- Using fiber-optic confocal microscopy and a calcium indicator, researchers studied calcium signals in dopamine neurons during Pavlovian fear conditioning.
- They found that while some dopamine neurons responded to fear stimuli on the first day, they showed more dynamic responses on the second day, indicating that these neurons undergo changes in activity as fear conditioning progresses.
Article Abstract
Dopamine is broadly implicated in fear-related processes, yet we know very little about signaling dynamics in these neurons during active fear conditioning. We describe the direct imaging of calcium signals of dopamine neurons during Pavlovian fear conditioning using fiber-optic confocal microscopy coupled with the genetically encoded calcium indicator GCaMP3. We observed calcium transients in a subset of dopamine neurons to an unconditioned fear stimulus on the first day of Pavlovian fear conditioning. On the second day, calcium transients occurred in response to conditioned and unconditioned stimuli. These results demonstrate plasticity in dopamine neuron calcium signals and the occurrence of activity-dependent processes in these neurons during fear conditioning.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201808 | PMC |
| http://dx.doi.org/10.1101/lm.036079.114 | DOI Listing |
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