We study residual plots for parametric accelerated failure time (AFT) models, using both standardized residuals and Cox-Snell residuals. Two different approaches are discussed in the case of censored data; adjusting censored residuals by adding a residual time, and using nonparametric exponential regression of non-adjusted censored Cox-Snell residuals. The main object of the paper is to show how residuals can be used to infer the correct functional form for possibly misspecified covariates. We demonstrate the use of the methods by analysis of two reliability data sets and by a simulation study using Weibull-distributed data. We also consider briefly a corresponding approach for parametric proportional hazards models.
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http://dx.doi.org/10.1007/s10985-014-9311-y | DOI Listing |
Sci Rep
January 2025
Faculty of Life and Allied Health Sciences, MS Ramiah University of Applied Sciences (RUAS), MSR Nagar, New BEL Road, Bangalore, 560054, India.
Background Breast cancer represents a significant public health concern in India, accounting for 28% of all cancer diagnoses and imposing a substantial economic burden. This study introduces a novel approach to forecasting the number of breast cancer cases (based on prevalence rates) and estimating the associated economic impact in India using the autoregressive integrated moving average (ARIMA) model. Methods Data on the prevalence of breast cancer in India from 2000 to 2021 were obtained from the Global Burden of Disease (GBD) database.
View Article and Find Full Text PDFMolecules
December 2024
Institute of Chemistry, University of Campinas (UNICAMP), Campinas 13083-970, SP, Brazil.
In the analytical quality by design (AQbD) framework, the design of experiments (DOE) plays a very important role, as it provides information about how experimental input variables influence critical method attributes. Based on the information obtained from the DOE, mathematical models are generated and used to build the method operable design region (MODR), which is a robust region of operability. Data treatment steps are usually carried out in software such as Fusion QbD, Minitab, or StaEase 360, among others.
View Article and Find Full Text PDFFront Immunol
January 2025
University of Michigan, Department of Internal Medicine, Ann Arbor, MI, United States.
Introduction: Despite progress in systemic lupus erythematosus (SLE) treatment, challenges persist in medication adherence due to side effects and costs. Precision nutrition, particularly adjusting fatty acid intake, offers a cost-effective strategy for enhancing SLE management. Prior research, including our own, indicates that increased consumption of omega-3 polyunsaturated fatty acids (PUFAs) correlates with improved outcomes in SLE patients.
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December 2024
Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Venusberg Campus 1, 53127, Bonn, Germany.
Postpartum urinary retention has a wide range of publicized incidences, likely caused by frequent misdiagnosis of this puerperal complication. Especially covert postpartum urinary retention has a high number of missed diagnoses due to the lack of symptoms and the time-extensive diagnostics via ultrasound, leading to no treatment and no appropriate follow-up. To simplify the diagnosis and establish a screening tool we analyzed the application of portable handheld-ultrasound devices (PUD) as used in Point-of-care diagnostics in comparison to established standard ultrasound devices (SUD).
View Article and Find Full Text PDFHeliyon
January 2024
Food Laboratory Department, Food and Drugs Authority, Post Office Box CT2783, Cantonments, Accra, Ghana.
Introduction: Potassium bromate (KBrO) is an oxidizing agent added to flour to improve bread quality. However, KBrO is nephrotoxic, and a class B carcinogen banned in most countries, including Ghana.
Aim: This study aimed to determine the residual KBrO concentration in bread and to estimate the chemical and carcinogenic risk that is associated with the consumption of these breads in Ghana.
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