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Manipulating a "cocaine engram" in mice. | LitMetric

Manipulating a "cocaine engram" in mice.

J Neurosci

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and

Published: October 2014

AI Article Synopsis

  • Experiences with drugs like cocaine create strong memories that contribute to addiction, but the specific brain processes behind these memories are still not fully understood.
  • Researchers used mice to investigate the brain circuits involved in cocaine-related memories and identified a small group of neurons in the lateral nucleus of the amygdala as key players in memory formation.
  • The study highlights the role of a protein called CREB in these neurons, which is crucial for both forming and recalling cocaine memories, pointing towards potential strategies for treating drug addiction.

Article Abstract

Experience with drugs of abuse (such as cocaine) produces powerful, long-lasting memories that may be important in the development and persistence of drug addiction. The neural mechanisms that mediate how and where these cocaine memories are encoded, consolidated and stored are unknown. Here we used conditioned place preference in mice to examine the precise neural circuits that support the memory of a cocaine-cue association (the "cocaine memory trace" or "cocaine engram"). We found that a small population of neurons (∼10%) in the lateral nucleus of amygdala (LA) were recruited at the time of cocaine-conditioning to become part of this cocaine engram. Neurons with increased levels of the transcription factor CREB were preferentially recruited or allocated to the cocaine engram. Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Consistent with theories that coordinated postencoding reactivation of neurons within an engram or cell assembly is crucial for memory consolidation (Marr, 1971; Buzsáki, 1989; Wilson and McNaughton, 1994; McClelland et al., 1995; Girardeau et al., 2009; Dupret et al., 2010; Carr et al., 2011), we also found that post-training suppression, or nondiscriminate activation, of CREB overexpressing neurons impaired consolidation of the cocaine memory. These findings reveal mechanisms underlying how and where drug memories are encoded and stored in the brain and may also inform the development of treatments for drug addiction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705287PMC
http://dx.doi.org/10.1523/JNEUROSCI.3327-14.2014DOI Listing

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