AI Article Synopsis
- - Microvesicles (MVs) from leukemia cells are significant in the leukemia microenvironment and may contain unique microRNAs (miRNAs) that can help us understand their development.
- - The study analyzed the miRNA expression patterns of MVs derived from different cell lines (Nalm-6 and Jurkat) as well as normal cells, revealing 182 and 166 differentially expressed miRNAs, respectively.
- - The research identified that these miRNAs target various oncogenes and tumor suppressor genes, which could play a role in the progression of Acute Lymphoblastic Leukemia (ALL), thereby improving diagnostic markers and insights into its pathogenesis.
Article Abstract
Microvesicles (MVs) are the heterogeneous mixtures of vesicles. MVs released by leukemia cells constitute an important part of the leukemia microenvironment. MVs might act as important reservoirs of microRNAs (miRNAs). It is worth evaluating whether MVs possess some unique miRNA contents that are valuable in understanding the pathogenesis. In this study, we investigated the miRNA expression patterns of Nalm-6-derived MVs, Jurkat-derived MVs and normal cell-derived MVs using miRNA microarrays. The potential target genes regulated by differentially expressed miRNAs were also predicted and analyzed. Results demonstrated that 182 miRNAs and 166 miRNAs were differentially expressed in Nalm-6-MVs and Jurkat-MVs, respectively. Many oncogenes, tumor suppressors and signal pathway genes were targeted by these aberrantly expressed miRNAs, which might contribute to the development of B-ALL or T-ALL. Our findings expanded the potential diagnostic markers of ALL and provided useful information for ALL pathogenesis.
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| http://dx.doi.org/10.1007/s11596-014-1330-0 | DOI Listing |
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