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Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin.
Nutr Res
October 2021
Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA.
Article Synopsis
- E2, or 17-beta-estradiol, influences hair cycling, differentiation, and sebum production, as well as the metabolism of vitamin A in the pilosebaceous unit (PSU).
- The study involved treating male and female mice with E2 or its inhibitors, revealing that E2 regulates vitamin A metabolism differently based on sex, with significant effects seen in females.
- Findings suggest that estrogen's interaction with vitamin A could have implications for conditions like acne, hair loss, and skin immunity.
Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil.
J Invest Dermatol
July 2017
Dermira, Inc., Menlo Park, California, USA. Electronic address:
Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis. Inhibition of ACC activity in the sebaceous glands is designed to substantially affect sebum production, because over 80% of human sebum components contain fatty acids. OG inhibits de novo lipid synthesis in primary and transformed human sebocytes.
View Article and Find Full Text PDFA Topical Medication of All-Trans Retinoic Acid Reduces Sebum Excretion Rate in Patients With Forehead Acne.
Am J Ther
March 2017
1Department of Dermatology and Venereology, Beijing Jishuitan Hospital, Beijing, China; 2Department of Bone Tissue Engineering Lab, Beijing Traumatology and Orthopedics Research Institute, Beijing Jishuitan Hospital, Beijing, China; and 3Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Acne is a disease of the hair follicles of the face, chest, and back that affects almost all teenagers during puberty. This study is conducted to investigate if all-trans retinoic acid (ATRA) could reduce sebum excretion rate (SER) in acne patients by influencing content of skin-surface lipid production. Thirty-nine patients with forehead acne were topically treated with cream base (vehicle) and 0.
View Article and Find Full Text PDFImmunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.
J Invest Dermatol
July 2007
Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Retinoic acid (RA) is essential for maintenance of most epithelial tissues. One RA biosynthesis pathway consists of cellular retinol-binding protein (Crbp), retinol dehydrogenase (Dhrs9/eRoldh), retinal dehydrogenase 1-3 (Aldh1a1-3), and cellular RA-binding protein 2 (Crabp2). Previously, we localized Aldh1a2 and Aldh1a3 to both epithelial and mesenchymal cells within the hair follicle throughout the hair cycle.
View Article and Find Full Text PDFEpidermal growth factor and 1alpha,25-dihydroxyvitamin D3 suppress lipogenesis in hamster sebaceous gland cells in vitro.
J Invest Dermatol
October 2001
Department of Biochemistry, Tokyo University of Pharmacy and Life Science, School of Pharmacy, Hachioji, Tokyo, Japan.
We have previously reported the establishment of a culture system of hamster auricular sebocytes. Although their morphologic and biochemical properties are very similar to those of human sebocytes, the regulation of lipogenesis is not clear. Therefore, we investigated the effect of epidermal growth factor, all-trans retinoic acid, 1alpha,25-dihydroxyvitamin D3, and androgens such as testosterone and 5alpha-dihydrotestosterone on lipogenesis in cultured hamster sebocytes.
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